Abstract: The monofactorial experiment was conducted to investigate the effects of salinity, density and sediment on the survival and growth of Sanguinolaria diphos juveniles.7 salinity gradients (10~40), 5 density gradients (500~10 000 ind/m²) and 5 sediment types (fine sand, 90% fine sand+10% mud, 80% fine sand+20% mud, 70% fine sand+30% mud, coarse sand) were set up.The results indicated that the growth and survival rate of salinity experimental groups (20, 25 and 30) were not significant difference (P>0.05);The growth and survival rate of Sanguinolaria diphos juveniles were significant difference (P<0.05) under different density conditions.The effect of different types of sediment on the growth was obvious.The appropriate growth salinity ranged from 20 to 25;The appropriate breeding density was found from 500 to 1 000 ind/m²;The most appropriate sediment was fine sand.The research result provided a theoretical reference for Sanguinolaria diphos artificial aquaculture in the pond.