Abstract: To ensure the quality and safety of fish scale collage product, the process of fish scale collagen production by enzymatic method was discussed, and internal control standard of materials, control standard of key process, and enterprise's standard of product were developed.The full quality control system of fish scale collagen from raw materials to end products package was established.Practice showed, after the quality system implementation, the result was as follow:the indexes of scale collagen products all conformed to requirements of enterprise's standards.