Abstract: As an important structural protein in the body,collagen is an important biological material with a wide range of sources and excellent biological properties:low immunogenicity,biodegradability,and cell compatibility.However,due to its own shortcomings,such as:rapid degradation,low thermal denaturation temperature,poor mechanical strength,etc.,its scope of applicationwas limited.At present,the commonly used method is to modify collagen,thereby effectively improving the performance of collagen in specific aspects,effectively responding to the performance needs of collagen in different fields,and expanding the application range of collagen.The article mainly introduced five modified methods, including chemical modification of collagen,chemical modification of side chain,modification of graft copolymerization,physical modification method,polymer material blend modification method.The application and progress of modified collagen in medical materials,food industry,papermaking,adhesives,leather industry and other fields,and the research and application trend of modified collagen were prospected.