Abstract: Fugu flavidus is good nutritional value and multi-purpose, which is wide-used in different fields. Its culture in mud ponds will add culture species and improve its profits in mud culture. The paper will provide a technical guide of its culture based on daily management, feeding and water quality management, disease preventing and cure. Fugu flavidus grows quickly in mud ponds with weight-growth rate of 0.658g/day , and the survival rate is 86.7%. There is two feeding peak with dawning and dusk, the time of feeding is about 1-2hours, and the amount of feed of dawning accounts for 1/3 of total daily amount. The Daily feeding rate is 2.0～3.0% in early-stage, and 1.5～2.0% in late-stage, which have to be modified in abnormal condition. The amount of water exchange is 20%～40%. According to the principle of “prevention is first combined with treatment”, the disease will be control, prevented and treated mainly with the management of water quality, feed and drugs using.