Abstract: According to the monitoring data of heavy metals (Hg, As, Cu,Pb and Cd) in Mytilus edulis from 2005 to 2011 in the sea areas of the special marine reserve of ShengSi MaAn Islands, we evaluated the safety and the healthy quality of Mytilus edulis. The results were obtained as follows:(1) The sequence of heavy metal contents in Mytilus edulis was Cu>Cd>As>Pb>Hg, the content of Cu was highest, and the contents of Pb and Cd belonged to the first class of marine biological quality standard.(2) The contents of As and Cd in Mytilus edulis highly exceeded the limit standard of "non-environmental pollution food, the limit for the deleterious matters in the aquatic product". The government should pay high attention to this issue.