Research progress on preparation,purification and structure activity relationship of ACE inhibitory peptide

In this study, ACE inhibitory peptide was a biologically active peptide with blood pressure lowering effect prepared by food-based processing.It contained a variety of potential physiological activities such as anti-oxidation, anti-inflammatory, and anti-obesity.The purified peptide sequence was interacted with ACE to study its structure-activity relationship.ACE inhibitory peptide was natural and reliable, non-toxic and safe, gradually replaced artificial chemical antihypertensive inhibitors and had been widely concerned and applied in the food industry.Therefore, to summarize the knowledge of ACE inhibitory peptides, the advances in the preparation, isolation and purification, molecular simulation, in vivo expression of spontaneously hypertensive rats and in vitro functional activity evaluation of polypeptides were reviewed.It is expected to provide valuable reference for the further development of ACE inhibitory peptide in the field of processing and production.